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A study by Dnicke et al
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This is typically a painful illness resulting is severe belly pain which can sometimes radiate to the back, nausea, vomiting, and possibly fevers
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After decades with no disease-modifying drug, 20242026 finally delivered the first targeted therapies: Novartis ianalumab met both NEPTUNUS-1 & NEPTUNUS-2 Phase 3 endpoints and won FDA Breakthrough Therapy status in Jan 2026, and J&Js nipocalimab was positive in the Phase 2 DAHLIAS trial ( The Lancet )
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